{"id":4380,"date":"2024-11-22T13:49:00","date_gmt":"2024-11-22T12:49:00","guid":{"rendered":"https:\/\/www.ofg-analytik.de\/examples\/failure-analysis-of-pharmaceutical-products-in-any-dosage-form\/"},"modified":"2026-04-08T10:00:18","modified_gmt":"2026-04-08T08:00:18","slug":"failure-analysis-of-pharmaceutical-products-in-any-dosage-form","status":"publish","type":"page","link":"https:\/\/www.ofg-analytik.de\/en\/examples\/failure-analysis-of-pharmaceutical-products-in-any-dosage-form\/","title":{"rendered":"Failure analysis of pharmaceutical products in any dosage form"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4380\" class=\"elementor elementor-4380 elementor-4241\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-483464a elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"483464a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9180508\" data-id=\"9180508\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3e3ccdc elementor-widget elementor-widget-heading\" data-id=\"3e3ccdc\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 24-06-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><div class=\"elementor-heading-title elementor-size-default\">Application examples<\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a105333 elementor-widget__width-initial elementor-widget elementor-widget-heading\" data-id=\"a105333\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Failure analysis of pharmaceutical products in any dosage form <\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-31e42e3 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"31e42e3\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-ee5b1ca\" data-id=\"ee5b1ca\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b62b744 elementor-widget elementor-widget-heading\" data-id=\"b62b744\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Material analysis using TOF-SIMS in pharmacy: application examples<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a535ba6 elementor-widget elementor-widget-text-editor\" data-id=\"a535ba6\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 24-06-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Pharmaceutical products exist in countless dosage forms: Tablets, capsules, coated tablets, powders, ointments, creams and plasters. Each of these products is subject to the strictest quality requirements due to the excipients and active ingredients they contain. Even the smallest traces of foreign material or impurities can impair their effectiveness. This can result in side effects or endanger the patient.   <\/p>\n<p>The cause of such impurities can be foreign contamination from manufacturing or packaging processes. Instrumental analysis is an indispensable tool for testing the chemical composition of pharmaceutical products. The choice of analytical methods is limited by different dosage forms, complex layer structures or the combination of different excipients and active ingredients. The TOF-SIMS method (time-of-flight secondary ion mass spectrometry) offers the possibility of precise material and damage analysis of pharmaceutical products   <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-38e8125\" data-id=\"38e8125\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e8e5b0e elementor-widget elementor-widget-image\" data-id=\"e8e5b0e\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.22.0 - 24-06-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/schadensanalyse-pharmazie-1-min.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"schadensanalyse-pharmazie-1-min\" data-e-action-hash=\"#elementor-action%3Aaction%3Dlightbox%26settings%3DeyJpZCI6NDI5NywidXJsIjoiaHR0cHM6XC9cL3d3dy5vZmctYW5hbHl0aWsuZGVcL3dwLWNvbnRlbnRcL3VwbG9hZHNcLzIwMjRcLzExXC9zY2hhZGVuc2FuYWx5c2UtcGhhcm1hemllLTEtbWluLmpwZyJ9\">\n\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/schadensanalyse-pharmazie-1-min.jpg\" class=\"attachment-full size-full wp-image-4297\" alt=\"Materialanalyse mittels TOF-SIMS in der Pharmazie\" srcset=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/schadensanalyse-pharmazie-1-min.jpg 800w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/schadensanalyse-pharmazie-1-min-300x300.jpg 300w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/schadensanalyse-pharmazie-1-min-150x150.jpg 150w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/schadensanalyse-pharmazie-1-min-768x768.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fa34c83 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fa34c83\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-299ffb7\" data-id=\"299ffb7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-a4c08d4\" data-id=\"a4c08d4\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-94e4ff1 elementor-widget elementor-widget-image\" data-id=\"94e4ff1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/schadensanalyse-pharmazie-2-min.jpg\" data-elementor-open-lightbox=\"no\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1200\" height=\"944\" src=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/schadensanalyse-pharmazie-2-min.jpg\" class=\"attachment-full size-full wp-image-4299\" alt=\"Dosage forms of pharmaceutical products\" srcset=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/schadensanalyse-pharmazie-2-min.jpg 1200w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/schadensanalyse-pharmazie-2-min-300x236.jpg 300w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/schadensanalyse-pharmazie-2-min-1024x806.jpg 1024w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/schadensanalyse-pharmazie-2-min-768x604.jpg 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">The dosage forms of pharmaceutical products limit the choice of analytical methods. The TOF-SIMS method is not affected by this.<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-1aeb0b2\" data-id=\"1aeb0b2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2e5af7a elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2e5af7a\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a669fc6\" data-id=\"a669fc6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1235ae8 elementor-widget elementor-widget-heading\" data-id=\"1235ae8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">TOF-SIMS: Method for the analysis of pharmaceutical products<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a6f55c8 elementor-widget elementor-widget-text-editor\" data-id=\"a6f55c8\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>TOF-SIMS is a highly sensitive method in instrumental analysis. It enables the chemical characterization of pharmaceutical products down to the trace level. In addition to the detection of active ingredients, additives and fillers, the method enables the identification of contaminants. In addition, the layer structure (galenics) can be mapped &#8211; all without being restricted by the dosage form.   <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38e32b1 elementor-widget elementor-widget-heading\" data-id=\"38e32b1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Problems\/issues for dosage forms: Examples<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dbd9b57 elementor-widget elementor-widget-text-editor\" data-id=\"dbd9b57\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<ul>\n<li><strong>Plasters<\/strong>: What is the chemical composition of the outer layer?<\/li>\n<li><strong>Nasal spray<\/strong>: Which active ingredients and additives can be chemically characterized?<\/li>\n<li><strong>Pellets<\/strong>: What does the layer structure look like?<\/li>\n<li><strong>Tablets<\/strong>: What is the chemical cause of the discoloration\/staining on tablets?<\/li>\n<li><strong>Eye drops<\/strong>: Can impurities be chemically identified?<\/li>\n<li><strong>Ointment<\/strong>: What causes the discoloration?<\/li>\n<li><strong>Coating<\/strong>: What is the chemical composition of the colored coatings?<\/li>\n<li><strong>Injection solution<\/strong>: What is the chemical composition of the impurities?<\/li>\n<li><strong>Atomizer<\/strong>: What is the chemical composition of the foreign particles? <\/li>\n<li><strong>Suspension<\/strong>: What is the active ingredient composition of the pharmaceutical product?<\/li>\n<\/ul>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bedc613 elementor-widget elementor-widget-text-editor\" data-id=\"bedc613\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>The combination of a large number of excipients, fillers and active ingredients, as well as different dosage forms, can give rise to various quality assurance problems. Specific application examples include the contamination of citalopram tablets by zinc bromide. <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17d5f2e elementor-widget elementor-widget-heading\" data-id=\"17d5f2e\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Results and imaging of TOF-SIMS analysis of pharmaceutical products<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-508483f elementor-widget elementor-widget-text-editor\" data-id=\"508483f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p class=\"p1\">In contrast to many other methods of instrumental analysis, TOF-SIMS is not limited to the chemical analysis of individual special substances and substance groups. Due to its high sensitivity, the TOF-SIMS method enables the identification of all species present. In addition, the method offers spatially resolved visualization of the detected chemical substances. Depending on the analysis objective, the data can be visualized as mass spectra or as spatially resolved images.   <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3d6378f elementor-widget elementor-widget-heading\" data-id=\"3d6378f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Case studies <\/h4>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1bff32e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1bff32e\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-14163e6\" data-id=\"14163e6\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-507b0ab elementor-widget elementor-widget-heading\" data-id=\"507b0ab\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Identification of the combination of active ingredients in a veterinary medicine <\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fe6a2f7 elementor-widget elementor-widget-text-editor\" data-id=\"fe6a2f7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>One advantage of the TOF-SIMS method for material analysis of pharmaceutical products is the identification of all substances contained in just one measurement. In this example, both active ingredients (paracetamol and meloxicam) contained in a veterinary medicine are detected. <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-934179e elementor-widget elementor-widget-image\" data-id=\"934179e\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"302\" src=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2025\/05\/Materialanalyse-TOF-SIMS-Veterinaermedikament-1.jpg\" class=\"attachment-large size-large wp-image-5204\" alt=\"Materialanalyse -an-Tabletten:-Gleichzeitiger-Nachweis-von-Paracetamol-und-Meloxicam\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">Materialanalyse an Tabletten: Gleichzeitiger Nachweis von Paracetamol und Meloxicam<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-83f0f05\" data-id=\"83f0f05\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4483b47 elementor-widget elementor-widget-heading\" data-id=\"4483b47\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">TOF-SIMS imaging for spatially resolved material analysis <\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e37de64 elementor-widget elementor-widget-text-editor\" data-id=\"e37de64\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Galenics play an important role in the efficacy of pharmaceutical products. With the help of TOF-SIMS imaging analysis, the layer structure of these products can be tested precisely and with high spatial resolution. The illustration shows the spatially resolved material analysis of an omeprazole preparation using a TOF-SIMS image.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38ad1cd elementor-widget elementor-widget-image\" data-id=\"38ad1cd\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"316\" src=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/OmeprazolBildSeite3Bild4-min-1024x404.jpg\" class=\"attachment-large size-large wp-image-4314\" alt=\"Materialanalyse TOF-SIMS Image\" srcset=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/OmeprazolBildSeite3Bild4-min-1024x404.jpg 1024w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/OmeprazolBildSeite3Bild4-min-300x118.jpg 300w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/OmeprazolBildSeite3Bild4-min-768x303.jpg 768w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/OmeprazolBildSeite3Bild4-min.jpg 1500w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">TOF-SIMS Image of an omeprazole pellet<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-bf04563 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bf04563\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-5459581\" data-id=\"5459581\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3fd067a elementor-widget elementor-widget-heading\" data-id=\"3fd067a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Surface analysis of impurities in pharmaceutical products <\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-498e404 elementor-widget elementor-widget-text-editor\" data-id=\"498e404\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p class=\"p1\">The smallest impurities in pharmaceutical products, such as tablets, can impair their effectiveness. The TOF-SIMS method enables foreign contaminants and foreign substances to be clearly identified. In the example below, zinc bromide was chemically identified as the cause of the dark spots in addition to the active ingredient citalopram and excipients.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fdeeeba elementor-widget elementor-widget-image\" data-id=\"fdeeeba\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"763\" src=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/TabletteFleckSeite4Bild6-min.jpg\" class=\"attachment-large size-large wp-image-4324\" alt=\"\" srcset=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/TabletteFleckSeite4Bild6-min.jpg 800w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/TabletteFleckSeite4Bild6-min-300x286.jpg 300w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2024\/11\/TabletteFleckSeite4Bild6-min-768x732.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dfa0c3a elementor-widget elementor-widget-image\" data-id=\"dfa0c3a\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"290\" src=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2025\/05\/Materialanalyse-TOF-SIMS-Tablette-Citalopram-1024x371.jpg\" class=\"attachment-large size-large wp-image-5202\" alt=\"TOF-SIMS Materialanalyse von Verunreinigungen\/Flecken auf Tabletten: Zinkbromid in Antidepressiva\" srcset=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2025\/05\/Materialanalyse-TOF-SIMS-Tablette-Citalopram-1024x371.jpg 1024w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2025\/05\/Materialanalyse-TOF-SIMS-Tablette-Citalopram-300x109.jpg 300w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2025\/05\/Materialanalyse-TOF-SIMS-Tablette-Citalopram-768x278.jpg 768w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2025\/05\/Materialanalyse-TOF-SIMS-Tablette-Citalopram-1536x556.jpg 1536w, https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2025\/05\/Materialanalyse-TOF-SIMS-Tablette-Citalopram-2048x742.jpg 2048w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">TOF-SIMS Materialanalyse von Verunreinigungen\/Flecken auf Tabletten: Zinkbromid in Antidepressiva<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1798b6c\" data-id=\"1798b6c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c5678d3 elementor-widget elementor-widget-heading\" data-id=\"c5678d3\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Identification of substances in the higher mass range<\/h5>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-79b9735 elementor-widget elementor-widget-text-editor\" data-id=\"79b9735\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p class=\"p1\">TOF-SIMS is also characterized by the fact that it is not subject to the typical limitations of many other methods. It enables the simultaneous analysis of elements or compounds of small and large masses. During the chemical analysis of a nasal spray, the active ingredient desmopressin and substances based on quaternary ammonium compounds <g id=\"gid_0\">(<\/g>biocides) were detected.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-75cb2d9 elementor-widget elementor-widget-image\" data-id=\"75cb2d9\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"306\" src=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2025\/05\/Materialanalyse-TOF-SIMS-Nasenspray-1.jpg\" class=\"attachment-large size-large wp-image-5198\" alt=\"Materialanalyse-TOF-SIMS-QAVs\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ef998b8 elementor-widget elementor-widget-image\" data-id=\"ef998b8\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t<figure class=\"wp-caption\">\n\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"302\" src=\"https:\/\/www.ofg-analytik.de\/wp-content\/uploads\/2025\/05\/Materialanalyse-TOF-SIMS-Nasenspray-2-1.jpg\" class=\"attachment-large size-large wp-image-5206\" alt=\"TOF-SIMS Spektrum eines Nasensprays: Identifizierung des Wirkstoffes\nDesmopressin und von quart\u00e4ren Ammoniumverbindungen\" \/>\t\t\t\t\t\t\t\t\t\t\t<figcaption class=\"widget-image-caption wp-caption-text\">TOF-SIMS Spektrum eines Nasensprays: Identifizierung des Wirkstoffes\nDesmopressin und von quart\u00e4ren Ammoniumverbindungen<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-0275bf7 elementor-widget elementor-widget-heading\" data-id=\"0275bf7\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Summary of results: TOF-SIMS for precise damage analysis and quality control <\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8df20be elementor-widget elementor-widget-text-editor\" data-id=\"8df20be\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p class=\"p1\">Precise chemical analyses using TOFSIMS down to the \u00b5m range enable the reliable identification of chemical substances. In this way, the cause of quality deviations such as impurities, discoloration, residues, foreign particles and other material defects can be found. <\/p>\n<p>Contact us if you have any questions about the chemical composition and layer structure of your pharmaceutical products. We support you in troubleshooting and damage analysis as well as in monitoring the long-term stability (degradation) of your products. Our team will be happy to help you with any questions or problems you may have &#8211; also in other sectors.  <\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Application examples Failure analysis of pharmaceutical products in any dosage form Material analysis using TOF-SIMS in pharmacy: application examples Pharmaceutical products exist in countless dosage forms: Tablets, capsules, coated tablets, powders, ointments, creams and plasters. Each of these products is subject to the strictest quality requirements due to the excipients and active ingredients they contain. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3718,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"footnotes":""},"class_list":["post-4380","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.ofg-analytik.de\/en\/wp-json\/wp\/v2\/pages\/4380","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ofg-analytik.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.ofg-analytik.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.ofg-analytik.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ofg-analytik.de\/en\/wp-json\/wp\/v2\/comments?post=4380"}],"version-history":[{"count":9,"href":"https:\/\/www.ofg-analytik.de\/en\/wp-json\/wp\/v2\/pages\/4380\/revisions"}],"predecessor-version":[{"id":5442,"href":"https:\/\/www.ofg-analytik.de\/en\/wp-json\/wp\/v2\/pages\/4380\/revisions\/5442"}],"up":[{"embeddable":true,"href":"https:\/\/www.ofg-analytik.de\/en\/wp-json\/wp\/v2\/pages\/3718"}],"wp:attachment":[{"href":"https:\/\/www.ofg-analytik.de\/en\/wp-json\/wp\/v2\/media?parent=4380"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}